Drosophila KDEL Receptor Function in the Embryonic Salivary Gland and Epidermis

Drosophila KDEL Receptor Function in the Embryonic Salivary Gland and Epidermis

Core components of the secretory pathway have largely been identified and studied in single cell systems such as the budding yeast S. cerevisiae or in mammalian tissue culture. These studies provide details on the molecular functions of the secretory machinery; they fail, however, to provide insight into the role of these proteins in the context of specialized organs of higher eukaryotes. Here,...

CrebA regulates secretory activity in the Drosophila salivary gland and epidermis.

Understanding how organs acquire the capacity to perform their respective functions is important for both cell and developmental biology. Here, we have examined the role of early-expressed transcription factors in activating genes crucial for secretory function in the Drosophila salivary gland. We show that expression of genes encoding proteins required for ER targeting and translocation, and p...

Embryonic Salivary Gland Branching Morphogenesis

Salivary submandibular gland (SMG) morphogenesis is regulated by the functional integration of stage-specific growth factor, cytokineand transcription factor-mediated signaling which mediates specific patterns of cell proliferation, cell quiescence, apoptosis, and histodifferentiation. We describe the stage-specific distribution of protein components of key signaling pathways during embryonic S...

Receptor guanylyl cyclase Gyc76C is required for invagination, collective migration and lumen shape in the Drosophila embryonic salivary gland

The Drosophila embryonic salivary gland is formed by the invagination and collective migration of cells. Here, we report on a novel developmental role for receptor-type guanylyl cyclase at 76C, Gyc76C, in morphogenesis of the salivary gland. We demonstrate that Gyc76C and downstream cGMP-dependent protein kinase 1 (DG1) function in the gland and surrounding mesoderm to control invagination, col...

Salivary gland function